Extended Data Fig. 2: Contribution of each genetic feature on the GPS.
From: Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications
Shown is a violin plot demonstrating the contribution of each genetic feature to the 919,809 genetic priority scores in the Open Target dataset for n = 231,066 gene-phenotype combinations. The plot shows the contribution of each feature to the GPSs compared across all features and all scores, binned according to the percentile of the score. The violin width represents the density of the genetic feature at each percentile and the mean percentile for each feature is shown as a point. On the y-axis, the sample size (n) and mean weight of each genetic feature from the five cross-validated samples was recorded and the y-axis was ordered by increasing value of these weights. We demonstrate that many different genetic features contribute to the highest percentile ranked GPSs.
