Extended Data Fig. 9: Heritability explained by molecular QTL. | Nature Genetics

Extended Data Fig. 9: Heritability explained by molecular QTL.

From: Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Extended Data Fig. 9

(A) Heritability enrichment results for the 9 additional GWAS not shown in Fig. 6c. A 95% confidence interval is displayed. (B) Bar plots, mean values +/- SEM, representing the percent of heritability explained by each of the molecular QTL in all conditions. (C) Average heritability enrichment across independent GWAS traits (allergy and eczema, adult-onset asthma, MS, RA and IBD), comparing s-LDSC results using generic baseline, generic baseline and adjusting for s-LDSC’s histone marks, as well as generic baseline and adjusting for histone marks from the current study. s-LDSC analysis was conducted on finemapped molecular QTLs (using fine-mapping tool SuSiE), treating PIPs from fine-mapping results as continuous annotations. The average enrichments across all independent traits (error bars represent standard errors) are plotted with the p-value of enrichments from a random effects meta-analysis. (D) Height, BMI, and schizophrenia are shown as examples of negative controls. Mean values +/- SEM are reported. Little or no enrichment is seen, significantly less than reported immune traits.

Back to article page