Fig. 1: Overview of the 3D multiomic approach.
a, Study schematic. b–i, A and B compartment associations with the percentage of the genome covered (n = 80) (b), the percentage overlapping with genes (n = 80) (c), the mean transcripts per million (TPM) of the genes (n = 78) (d), the percentage overlapping with the 5hmC peaks (n = 52) (e), the percentage overlapping with PMDs (n = 69) (f), the percentage overlapping with HMRs (n = 69) (g), the percentage overlapping with mutations (n = 76) (h) and the percentage overlapping with SVs (n = 76) (i). Each point represents one sample. The dotted lines connect the values from the A and B compartments in the same sample. P values were computed using a paired, two-sided Wilcoxon rank-sum test. The center line represents the median; the box limits represent the upper and lower quartiles; and the whiskers represent 1.5× the interquartile range (IQR).
