Extended Data Fig. 6: Modeling the impact of ASM-QTL on methylation and expression.
From: The correlation between CpG methylation and gene expression is driven by sequence variants
Model diagrams (leftmost column) describing the four different hypotheses on the mechanism by which an ASM-QTL genotype (G) influences CpG methylation (M) and gene expression (E). The outcomes of two different tests (MR-Steiger and our method of comparing \({\hat{\beta }}_{{GM}}{\hat{\beta }}_{{GE}}\) and \({\hat{\sigma }}_{M}^{2}{\hat{\beta }}_{{ME}}\)) are shown; ‘v’ shape indicates that the model is supported by the test, whereas ‘x’ indicates that the model is not supported by the test and empty cells indicates that the test is unable to consider whether or not the model is supported. For clarity, each model is labelled with a number which are then used as reference to each diagram in the main text and in Fig. 3.
