Extended Data Fig. 7: Proportion of variants with high/moderate functional impact in cross-population biobank fine-mapping analyses.

The functional impact of each variant was annotated using VEP, with the definition and classification of functional impact obtained from https://useast.ensembl.org/info/genome/variation/prediction/predicted_data.html. The high impact category includes transcript ablation, splice acceptor variants and splice donor variants; the moderate impact category includes missense variants and protein-altering variants; the low impact category includes synonymous variants and splice region variants; the modifier impact category includes introns and intergenic variants among others.