Fig. 4: Validation of the latent factors across independent cohorts.
From: Five latent factors underlie response to immunotherapy
Forest plots illustrating the association of latent factors across groups of tumors with different origins in the HMF-CPI cohort (left) and across six independent cohorts (right) with CPI response and overall survival. The value of each latent factor was computed as the mean of the cluster of features obtained in the HMF-CPI cohort across each validation cohort, except in the VHIO cohort, where the transcriptomics latent factors were estimated from alternative sets of genes (Methods). In the forest plots, the dots represent the strength (coefficients estimated through multivariate logistic or Cox regression) of the association between the latent factor and response or survival across cohorts. The horizontal bars denote the 95% confidence intervals. Gray dots represent latent factors whose estimates are within one standard error at either side of 0, dots with a light color (green or red) represent non-significant associations with coefficient estimates above (or below) one standard error of 0 and dark-colored dots represent significant associations. Green dots represent positive associations with improved outcomes (higher response odds or lower hazard ratio), while red dots represent negative associations (lower response or higher hazard ratio). Mixed denotes cohorts integrated by patients with multiple tumor types.
