Extended Data Fig. 6: Examples of cell-type-specific sQTLs in known SLE risk genes. | Nature Genetics

Extended Data Fig. 6: Examples of cell-type-specific sQTLs in known SLE risk genes.

From: Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases

Extended Data Fig. 6

A total of 30 cell-type-specific cis-sQTLs affecting known risk genes in Systemic Lupus Erythematosus. The alternate allele of the lead SNP rs147291617 upregulated an intron junction (chr17:36103981-36104528) of CCL4 in a cell-type-specific fashion. Dark blue blocks in the left panel indicates the existence of cis-sQTL. Red lines in violin plots in the right panel indicate the significant linear relationships between the junction ratios of chr17:36103981-36104528 and the genotype of rs147291617 in CD16+ Monocyte, CD16 + NK, cyt CD4 + T, em CD4 + T, GZMBhi CD8 + T, GZMKhi CD8 + T, MAIT, GZMKhi gdT and GZMBhi gdT. The lack of red lines in the violin plot of CD14+ Monocyte, IGHMhi memory B, and IGHMlo memory B indicates no significant relationship between the junction ratios of the intron and the genotype of rs147291617. The box plots show median and interquartile range (IQR), and whiskers and 1.5-fold IQR.

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