Extended Data Fig. 2: DA analysis, DE analysis and GO enrichment analysis of scRNA-seq data of PBMCs from eHHV-6B-positive and eHHV-6B-negative patients with SLE.
From: Blood DNA virome associates with autoimmune diseases and COVID-19
a, Beeswarm plot showing the distribution of adjusted log2(fold change) in abundance between cases and controls in neighborhoods, with eHHV-6B-positive patients with SLE as case (n = 4) and eHHV-6B-negative patients with SLE as control (n = 11). b, The DE analysis between cases and controls in neighborhood groups as in a. DE genes (FDR < 0.01 and |fold change| > 2) are colored in red and labeled by gene symbols. c–e, Left: gene-concept network (cneplot) in neighborhood groups 6, 7 and 18. It shows the linkage of the DE genes and the concepts (GO biological process). The color of the genes represents the fold change values, and the size of the GO terms represents the number of associated genes. Right: directed acyclic graph for GO enrichment analysis in neighborhood groups 6, 7 and 18. Circles represent the GO function, colored by their FDR. Arrows indicate the relationship between the upstream and downstream GO functions.
