Extended Data Fig. 5: Heatmap for GenePrio genes with two lines of evidence.

GenePrio genes with two lines of evidence. The five categories of evidence that were assessed to prioritize genes at GWAS loci: snRNA-seq (labelled as snRNA), gene was a top 10% marker gene for cardiomyocytes in left atrial tissue; Coding, gene had genome-wide significant loss-of-function variant or missense variant with predicted to be damaging effect; MAGMA, significant result for the gene in MAGMA analysis; PoPs, gene had a high PoPs score; eQTL, sentinel variant at locus had a significant eQTL to that gene in cardiac tissue. The genes are sorted from lowest to highest P-value at the sentinel variant of the locus. AF, atrial fibrillation; eQTL, expression quantitative trait locus; GWAS, genome-wide association study; MAF, minor allele frequency; MAGMA, Multi-marker Analysis of GenoMic Annotation; PoPS, polygenic priority score; snRNA-seq, single-nuclei RNA-sequencing.