Extended Data Fig. 6: QQ plot for enrichment of loci within Ensembl predicted active regions within tissue groups.

Empirical one-sided P-values for enrichment of signals within Ensembl predicted active regions within tissue groups. Panels a), e), i), m), q), and u) show enrichment for single variants, panels b), f), j), n), r), and v) show enrichment for aggregate tests, panels c), g), k), o), s), and w) show enrichment for sliding-window based aggregate tests, and panels d), h), l), p), t), and x) show enrichment for Ensembl regulatory region based aggregate tests. Panels a), to d) show enrichment within all predicted active regions, panels e) to h) show enrichment within CTCF binding sites, panels i) to l) for enhancers, m) to p) for open chromatin regions, q) to t) for promoters, and u) to x) for transcription factor binding sites. P-values were derived from the proportion of sampled variants with equal or higher overlap with annotated regions.