Fig. 2: Manhattan results of single-variant and aggregate pQTL analyses. | Nature Genetics

Fig. 2: Manhattan results of single-variant and aggregate pQTL analyses.

From: Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels

Fig. 2

Manhattan plots showing associations between cis variants and regions with circulating protein levels, after adjusting for associated common variants and all coding variants of the cognate gene. a–e, The x axis represents genomic position and the y axis shows −log10Ptwo-sided for our cis results across all proteins, split into single variants (a), coding aggregates (b), gene-centric regulatory (proximal) aggregates (c), intergenic and intronic regulatory aggregates (d) and sliding-window aggregates (e). The red lines represent Bonferroni’s significance thresholds (P ≤ 2.95 × 10−10 for single variants and P ≤ 8.71 × 10−9 for aggregate tests). P values are derived from two-sided tests from mixed linear models.

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