Extended Data Fig. 6: Type 2 and SFTPA2⁺ signature represent the feature of ETS⁻ prostate cancer.

a, Correlation between ABSOLUE estimated tumor purity and signature score of dLum cells. Dots were colored by the molecular subtypes. Error bands represent 95% confidence intervals of the correlation curve. b, Heatmap showing expression levels of selected genes in CPGEA. Expression level of each gene was transformed into row z score before visualization. c, Overview of the sampling strategy of the prostate of patient 1. d, Spatial transcriptomic slices of patient 1 color by CNV Leiden clusters. e, Heatmap grouped by CNV Leiden clusters showing CNA in each spot. f, Spatial transcriptomic slice color by gene signatures calculated by AddModuleScore. g, Overview of the sampling strategy of the prostate of patient 1 (top-left) and spatial transcriptomic slices of patient 1 color by CNV Leiden clusters. h, Heatmap grouped by CNV Leiden clusters showing CNA in each spot. i, Spatial transcriptomic slice colored by gene signatures calculated by AddModuleScore (left and middle) and expression level of SFTPA2 (right) in each spot.