Table 1 General characteristics of GAA expansions of all samples with biallelic GAA expansions in the UK Biobank

From: Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat expansions in patient cells and in mice

ID	EHv4: genotype	EHv4: genotype CI	Diagnosed with hereditary ataxia	Manual review: genotype quality	Manual review: summary of interruptions	Manual review: observed interruptions
1	135/135	68–149/90–189		Low	Pure	GAAA
2	129/129	58–152/85–206	Yes	Low	Pure	GAAA
3	127/127	73–149/95–184		Low	Pure
4	125/125	73–158/97–197		Medium	Interrupted	GAG
5	114/114	68–138/88–171	Yes	Medium	Pure	GAAA
6	112/112	64–139/87–176		High	Interrupted	GAG
7	109/109	53–143/81–197	Yes	Medium	Pure
8	109/109	62–135/85–172		High	Interrupted	GAG, GAAA
9	105/105	50–134/71–201		Medium	Interrupted	GAG
10	103/103	29–145/74–208		Medium	Interrupted	GAG
11	102/102	53–118/76–161		Low	Interrupted	GAG, GAAA
12	100/100	53–138/78–193		Low	Interrupted	GAG
13	100/100	49–146/78–207		Medium	Interrupted	GAG, GAAA
14	98/98	43–142/69–203		Medium	Pure
15	98/98	48–120/73–173		High	Interrupted	GAG, GAAA
16	96/96	51–121/75–165		High	Interrupted	GAG, GAAA
17	95/95	50–115/73–162	Yes	High	Pure	GAAA
18	90/90	47–127/70–195		Medium	Interrupted	GAG, GAAA
19	90/90	44–97/66–149		Medium	Interrupted	GAG
20	89/89	49–130/73–184		Medium	Interrupted	GAG
21	89/89	50–132/73–183		Low	Pure
22	85/85	53–121/75–163		Low	Interrupted	GAG
23	85/85	44–114/66–165		Medium	Pure
24	84/84	48–106/67–153		Medium	Interrupted	GAG, GAAA
25	83/83	38–121/63–178		Medium	Pure
26	82/82	49–94/64–129		High	Interrupted	GAG, GAAA
27	82/82	40–124/64–210		Medium	Interrupted	GAG, GAAA
28	82/82	48–102/65–151		Medium	Interrupted	GAG, GAAA
29	79/79	39–98/61–150		Medium	Interrupted	GAG
30	79/79	49–103/67–165		Medium	Interrupted	GAG, GAAA
31	66/66	45–84/59–114		High	Interrupted	GAG, GAAA

Supporting data are included in Supplementary Table 1 and Supplementary Note 1. ID, patient identifier; EHv4: genotype, the diploid FXN genotype reported by ExpansionHunter v.4 for this sample, in the format: ‘number of repeats in allele 1/number of repeats in allele 2’; EHv4: genotype CI, ExpansionHunter’s reported confidence intervals for the genotype, having the format: ‘allele1_lower_bound–allele1_upper_bound/allele2_lower_bound–allele2_upper_bound’ (Methods).

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Table 1 General characteristics of GAA expansions of all samples with biallelic GAA expansions in the UK Biobank

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