Extended Data Fig. 9: Clonality status between paired primary and metastatic samples. | Nature Genetics

Extended Data Fig. 9: Clonality status between paired primary and metastatic samples.

From: Longitudinal and multisite sampling reveals mutational and copy number evolution in tumors during metastatic dissemination

Extended Data Fig. 9

(a) Scatterplot showing paired mutations that appeared in both a primary sample and a metastatic sample from the same patient. Cancer cell fraction (CCF) of the mutation in the primary sample was plotted against CCF of the mutation in the metastatic sample. (b) Alluvial plot showing fate of cancer cell fraction (CCF) of mutations among patients with both a primary and a metastatic site sampled. This plot tracks how the clonality status, determined by CCF, changes in the metastatic site. Ind = indeterminate.

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