Extended Data Fig. 6: PES genes show focal interactions at multiple downstream enhancer loci. | Nature Genetics

Extended Data Fig. 6: PES genes show focal interactions at multiple downstream enhancer loci.

From: Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs

Extended Data Fig. 6

a, Representative contact maps depicting ‘PES genes’ along with corresponding tracks for CTCF, RAD21, H3K27ac, and PLOR2A ChIP–seq data displayed above the contact map. The quantification of stripe interaction intensity was aligned at the top, with the red arrow indicating the peak of focal interaction at the enhancer sites. b, Gene length distribution histogram comparing all expressed genes ≥50 kb, PES genes, and length-matched non-PES genes in GM12878 cells. c, Left: pile-up analysis comparing PES genes and non-PES genes centered at the TSS without rescaling of GM12878; right: the difference between stripy and non-stripy and quantification at the TSS.

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