Extended Data Fig. 3: DiscoverX BROMOscan selectivity screens.
From: BET bromodomain inhibitors regulate keratinocyte plasticity
TREESpot rendering of binding affinity for NVS-BET-1 and NVS-BET-2 screened at 1 µM concentration across a panel of 32 bromodomains indicated in black on the human bromodomain phylogenetic tree dendrogram. Bromodomain-containing proteins not part of panel shown in gray. Size of circle represents ligand binding affinity per given target expressed as percent control (DMSO = 100%), see Supplementary Dataset 1.
