Extended Data Fig. 5: Sequence comparison between different species.
From: Structural basis for diamide modulation of ryanodine receptor
Sequence comparison between different species. a, Sequence alignment of the CHL-binding segments. The CHL-coordinating residues are highlighted by green (conserved among all species), orange (conserved among mammals), yellow (conserved among insects), blue (conserved among the Lepidotera), and grey (difference between RyR1 and RyR2). The resistance mutations are indicated by red arrows. b, Phylogenetic analysis of RyRs from different species, including Lepidoptera (Chilo suppressalis RyR: AFN70719.1, Danaus plexippus RyR: OWR50158.1, Spodoptera frugiperda RyR: QCQ29110.1, Mythimna separate RyR: AWV67093.1, Tuta absoluta RyR: APC65631.1, Plutella xylostella RyR: NP_001296002.1), Coleoptera (Leptinotarsa decemlineata RyR: AHW99830.1, Tribolium castaneum RyR: NP_001308588.1), Hymenoptera (Apis mellifera RyR: XP_006569098.1, Ooceraea biroi RyR: XP_026830164.1), Diptera (Drosophila melanogaster RyR: NP_001246211.1, Bactrocera dorsalis RyR: AHY02115.1), Hemiptera (Bemisia tabaci RyR: AFK84957.1, Myzus persicae RyR: XP_022160123.1), Vertebrate (Homo sapiens RyR2: NP_001026.2, Homo sapiens RyR3: NP_001027.3, Xenopus tropicalis RyR1: XP_004917160.1, Danio rerio RyR1: NP_001096041.1, Meleagris gallopavo RyR1: NP_001290128.1, Bos Taurus RyR1: NP_001193706.1, Oryctolagus cuniculus RyR1: NP_001095188.1, Homo sapiens RyR1: NP_000531.2).
