Extended Data Fig. 7: Conformational changes of C3aR and C5aR1 activation.
From: Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins
a, b, c, Conformational changes upon C3aR activation induced by C3a (top) and C5aR1 activation induced by C5a (bottom) when compared with PMX53-bound inactive C5aR1, including rearrangement of PIF motif (a), alteration of DRF motif (b) and NPxxY motif (c). d, e, f, Conformational changes in the intracellular regions of the receptors when aligned the structures of C3a-bound C3aR with inactive C5aR1 (d), C5a-bound C5aR1 with inactive C5aR1 (e) and C3a-bound C3aR with C5a-bound C5aR1 (f). Lime green, active C3aR; slate, active C5aR1; gray, PMX53-bound inactive C5aR1 (PDB: 6C1R).
