Extended Data Fig. 8: Glycolytic metabolites binding regulated targetome acetylation.
From: Chemoproteomic mapping of the glycolytic targetome in cancer cells
(a) Fraction of lysines in quantified peptides vs. lysines in TRPs of the glycolytic targetome based on PTM annotation with iPTMnet. (b) Percentage of lysine acetylation in non-TRPs vs. TRPs retrieved from the same glycolytic target (n=913). Data represent the mean ± SEM and P value was determined by a paired, two-tailed Student’s t-test. (c) GO analysis showing diverse subcellular locations for the fraction of TRAP-assigned glycolytic targets that have been assigned as acetylation carriers by iPTMnet. The subcellular distribution pattern resembles that of the whole glycolytic targetome. (d) Distribution pattern of MFs summarized for the whole glycolytic targetome vs. MFs of the glycolytic targetome that have been documented as acetylation carriers by iPTMnet. (e) Number of acetylated lysines in TRPs of each assayed glycolytic metabolite based on iPTMnet.
