Extended Data Fig. 8: Structural changes in the extracellular and central vestibules.
From: Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily
a, Front view, with one subunit removed for clarity. Residues that form constrictions with their sidechains (Val 123 and Tyr 542) or mainchain (Glu 124) in the junction between extracellular and central vestibules are shown as sticks. The distances between each pair of residues from two subunits are shown as dashed lines and labeled. b-d, Top view from central vestibule, with all three subunits shown, highlighting the changes in distances between Tyr 542 (b), Glu 124 (c), and Val 123 (d). Apo and FMRFamide bound structures are shown in pink and cyan respectively.
