Extended Data Fig. 5: Suppression of Sigma-1 Receptor blocks ferroptosis.
From: CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes
a-b. Cell viability of MDA-MB-468 cells treated by indicated doses of RSL3 for 6 hours in the presence or absence of MINK1 antagonist DMX-5084 (10 μM, a), or Adenosine A1/A2 receptor antagonist Diphylline (10 μM, b). c-d. MDA-MB-468 cells were exposed to indicated doses of RSL3 for 8 hours with or without σ1R antagonist S1RA (50 μM, c) or BD1047 (100 μM, d). Viability data represent mean ± s.d. of n = 3 replicates from one representative of three independent experiments.
