Extended Data Fig. 2: The pharmacological profile of Lys05.
From: Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
a, Concentration-response curves for Lys05 inhibition of recombinant Kir channels (Kir1.1, n = 6; Kir2.1, n = 4; Kir2.2, n = 5; Kir2.3, n = 5; Kir3.2, n = 4; Kir4.1, n = 8; Kir4.2 Y355F, n = 5; and Kir4.1/5.1, n = 11). Data are means ± s.e.m. b, Concentration-response curves of Lys05 and respective reference compound against antidepressant-relevant channels, GPCRs and monoaminergic transporters. For GPCRs and transporters, graphs show one representative result performed in triplicate or quadruplicate of 3 independent experiments. For channels, graphs show average results of all cells measured (GluN1/GluN2A, n = 12; GluN1/GluN2B, n = 10; α1β3γ2 GABAA, n = 7; α5β3γ2 GABAA, n = 4; and AMPA receptors, n = 5). Data are means ± s.e.m.
