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Chemical Decoding of Spatial Biology

Nature Chemical Biology volume 21, pages 983–984 (2025)Cite this article

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The spatial organization of biomolecules helps orchestrate a range of biological processes; however, links between spatial organization and regulation of physiological and pathological processes can be difficult to unravel. The development of innovative tools and recently uncovered insights were discussed at the ‘Chemical Decoding of Spatial Biology’ symposium.

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References

  1. Palla, G., Fischer, D. S., Regev, A. & Theis, F. J. Nat. Biotechnol. 40, 308–318 (2022).

    Article  CAS  PubMed  Google Scholar 

  2. Lambert, S. A. et al. Cell 172, 650–665 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Rothman, J. E. & Orci, L. Nature 355, 409–415 (1992).

    Article  CAS  PubMed  Google Scholar 

  4. Seferbekova, Z., Lomakin, A., Yates, L. R. & Gerstung, M. Nat. Rev. Genet. 24, 295–313 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Parkin, J. & Cohen, B. Lancet 357, 1777–1789 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Bressan, D., Battistoni, G. & Hannon, G. J. Science 381, eabq4964 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Liu, Y. et al. CCS Chem. 5, 802–813 (2023).

    Article  CAS  Google Scholar 

  8. Heinzmann, K., Carter, L. M., Lewis, J. S. & Aboagye, E. O. Nat. Biomed. Eng. 1, 697–713 (2017).

    Article  PubMed  Google Scholar 

  9. Armingol, E., Officer, A., Harismendy, O. & Lewis, N. E. Nat. Rev. Genet. 22, 71–88 (2021).

    Article  CAS  PubMed  Google Scholar 

  10. Nat. Methods 21, 2195–2196 (2024).

  11. Nat. Methods 18, 1 (2021).

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Author notes

  1. These authors contributed equally: Ziqi Liu, Yan Zhang.

Authors and Affiliations

  1. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China

    Ziqi Liu, Xinyuan Fan & Peng R. Chen

  2. Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China

    Yan Zhang, Xinyuan Fan & Peng R. Chen

Authors
  1. Ziqi Liu
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  2. Yan Zhang
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  3. Xinyuan Fan
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  4. Peng R. Chen
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Corresponding authors

Correspondence to Xinyuan Fan or Peng R. Chen.

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The authors declare no competing interests.

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Liu, Z., Zhang, Y., Fan, X. et al. Chemical Decoding of Spatial Biology. Nat Chem Biol 21, 983–984 (2025). https://doi.org/10.1038/s41589-025-01910-7

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