Fig. 1: Overall structures of PTH–PTH1R–Gq complexes.
From: Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R
a, A schematic diagram representing the general signaling pathways of class B1 GPCRs. b, A schematic diagram representing transient signaling from the cell surface and prolonged signaling from the endosome. c,d. The combined cryo-EM density maps and ribbon models of PTH–PTH1R–Gq complexes in the upright (c) and tilted (d) states. The contour levels are set to 8.3 and 6.7, respectively. The density derived from the detergent micelle was removed by the solvent mask.
