Extended Data Fig. 5: IL-33-mediated suppression of NK cells is not dependent on neutrophils or alveolar macrophages. | Nature Immunology

Extended Data Fig. 5: IL-33-mediated suppression of NK cells is not dependent on neutrophils or alveolar macrophages.

From: ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

Extended Data Fig. 5

a-e, WT mice were treated with PBS or IL-33 on day 0 and 1, and the indicated mAb (or clodronate liposomes, C.L.) on day -1 and 1 followed by quantification of percent IFNγ+ or GzmB+ lung NK cells (after PI stimulation) and quantification for the indicated lung myeloid cells on day 3 (a; GzmB n = 10,9,9,10, and depicted myeloid cells n = 15 ,14,14,15, b; n = 8,8,8,9, c; n = 7, d,e, n = 6). Bar graphs indicate mean (±S EM) and show combined data of two (b-e) or three (a) independent experiments. Statistical analyses were calculated using one-way ANOVA with ns = not significant, and **** = p ≤ 0.0001.

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