Extended Data Fig. 5: Internal validation and prognosis of an ILC2/type 2 immune cell signature in human melanoma.
From: Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma
a,b, ILC2 infiltration probability is predicted from NanoString transcriptome profiles, which measures a panel of 730 genes. For each patient, the predicted infiltration probability is correlated with IHC markers (a) and immune cell infiltration estimates (b) from Pan Immune multiplex IHC obtained from that patient. Spearman correlation values are indicated. c, Analysis of the impact of enrichment of type 2 immune cell infiltration on melanoma patient survival using the publicly available TCGA database. Tumor infiltration probability was determined as described in the Methods using machine learning. Kaplan-Meier overall survival curves of metastatic melanomas (n = 367) plotted against the likelihood of high and low infiltration of tumors by ILC2. f, Kaplan-Meier survival statistical analysis was performed using a Log-rank test. p-value is indicated.
