Extended Data Fig. 2: Distribution and density of serum triglyceride and high sensitivity C-reactive protein (hsCRP) values by APOC3 rs138326449 genotype in the UK Biobank.
From: Apolipoprotein C3 induces inflammasome activation only in its delipidated form
Unadjusted serum levels of a, triglycerides (n = 430,833) and b, hsCRP (n = 426,774) among UK Biobank carriers of 0, 1 or 2 alternative (A) alleles of the APOC3 loss-of-function variant rs138326449 (IVS2 + 1G-A). Specifically, 0/0 indicates homozygosity of the reference (G) allele, 0/1 indicates heterozygosity and 1/1 indicates homozygosity of the alternative (A) allele. The data are shown in box-and-whisker plots (the bound of the box extends from the 25th to 75th percentiles and the whisker covers the minima and maxima) with the median marked by a center line, remaining distribution and kernel density estimations of each trait (outlier values ± 5 standard deviations from the mean were removed). Compared with rs138326449-G homozygotes, rs138326449-A heterozygotes demonstrate a 0.62 mmol/L decrease in median triglycerides (p = <2.00 ×10−16 by one-way ANOVA) and a 0.16 mg/L increase in median hsCRP (p = 1.54 × 10−5 by one-way ANOVA).
