Extended Data Fig. 3: G-CSF is not specific for APLAID.
Cytokine assessment by a multiplex assay in other autoinflammatory diseases including cryopyrin-associated periodic syndromes (CAPS) (n = 1/female/15-year-old), familial mediterranean fever (FMF) (n = 6/3females/3males/10-,45-,19-,19-.49-years-old), hyper-IgD with periodic fever syndrome (HIDS; n = 2/1female/1male/both 6-year-old), deficiency of adenosin deaminase-2 (DADA2) (n = 2/2 males/15 and 18-years-old) showed increased G-CSF levels relative to age- and sex-matched healthy control levels (n = 10). a) Colour mapping of cytokine heatmap represents mean values relative to control in pg/ml. b-k) Individual cytokine levels of all HC and patients with various autoinflammatory diseases are shown. The limit of detection (LOD) for each cytokine is indicated by a dotted line in each graph. Error bars represent mean ± SEM.Cytokine levels between two groups were determined by an unpaired two-sided Student’s t-test.
