Fig. 3: High serum levels of G-CSF in participants with APLAID.
a, Cytokine assessment by a multiplex assay in sera of two APLAID participants showed a relative elevation in G-CSF followed by increased levels of IL-1ß, IL-12 and M-CSF compared to ten sex-matched and age-matched healthy controls (HCs). Color mapping of cytokine heat map represents mean values relative to control in pg ml−1. b, Protein schematic and participant mutations in PLCG2. c,d, Longitudinal cytokine and CRP pattern of two APLAID participants (n = 2; Pat. 1 p.Ala708Pro/male/13 years old; Pat. 2 p.Leu845Phe/848Pro/female/21 years old) under various treatment regimens revealed persistent elevation of G-CSF in participants’ sera. Dashed line represents the cutoff for abnormal CRP values. Error bars represent the mean ± s.e.m. Cytokine levels between two groups were determined by an unpaired two-sided Student’s t-test. ABx, antibiotics; CRP, C-reactive protein; GC, glucocorticoids; IVIG, intravenous immunoglobulins.
