Extended Data Fig. 9: TCR recognition patterns of age-specific TCRs. | Nature Immunology

Extended Data Fig. 9: TCR recognition patterns of age-specific TCRs.

From: Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan

Extended Data Fig. 9

a, Gating strategy and CD69-PECy7 expression profiles of SKW-3-CD3+CD8+ TCR-expressing cell lines following stimulation with the single alanine mutant M158-66 peptides. (b) Frequency of maximum CD69-PECy7 MFI following stimulation with M158-66 alanine scan peptides for age-specific TCRs expressed on SKW-3-CD3+CD8+ cells (n = 3 independent experiments, median and range). Statistical analysis was performed using a two-sided Kruskal-Wallis with Dunn’s correction for multiple tests between the public and the age-specific TCRs (b). Exact significant p-values are indicated above the graphs.

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