Extended Data Fig. 2: BCG vaccination protects mice from weight loss against various strains of mouse-adapted Sarbecoviruses. | Nature Immunology

Extended Data Fig. 2: BCG vaccination protects mice from weight loss against various strains of mouse-adapted Sarbecoviruses.

From: BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Extended Data Fig. 2

a, Experimental outline and weight loss of mice following challenge. b, Gross lung discoloration score at day 2 or 4 post-challenge. c, Lung viral titer at day 2 or 4 post-challenge, as assessed by plaque assay. Data representative of one independent experiment; In a, b, c, for SHC014 MA15, n = 8 (BCG); For SARS-CoV MA15 n = 9 (BCG); n = 7 for all other groups. Mean±SEM values are plotted. Statistical analysis was performed by Two-way ANOVA with Sidak’s multiple comparisons test. *, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.0001.

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