Extended Data Fig. 10: Extended data showing impaired activation of lung myeloid cells following CD4+ T cell or IFN-γ depletion. | Nature Immunology

Extended Data Fig. 10: Extended data showing impaired activation of lung myeloid cells following CD4+ T cell or IFN-γ depletion.

From: BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Extended Data Fig. 10

CD86 median fluorescence intensity (MFI) of DCs in the lungs at day 21 post-BCG IV vaccination following CD4 depletion (top) and IFN-g depletion (bottom). Data representative of one independent experiment; n = 5 (BCG+Isotype), n = 6 (Unvaccinated and BCG+anti-CD4), n = 9 (BCG) in CD4 depletion; n = 4 (Unvaccinated) and n = 5 (rest of the groups) in IFN-g depletion. Statistical analysis was performed by One-way ANOVA with Tukey’s multiple comparison test. *, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.0001.

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