Fig. 2: Network analyses define key immune mediators in LC symptom groups.

Network analysis of Olink mediators associated with cardioresp (n = 365), fatigue (n = 314), anxiety/depression (n = 202), GI (n = 124) and cognitive groups (n = 60). Each node corresponds to a protein mediator identified by PLR. The edges (blue lines) were weighted according to the size of Spearman’s rank correlation coefficient between proteins. All edges represent positive and significant correlations (P < 0.05) after FDR adjustment.