Extended Data Fig. 6: Molecularly distinct MkPs generated by Vwf-tdTomato+ P-HSCs and Vwf-tdTomato– Multi-HSCs. | Nature Immunology

Extended Data Fig. 6: Molecularly distinct MkPs generated by Vwf-tdTomato+ P-HSCs and Vwf-tdTomato– Multi-HSCs.

From: Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells

Extended Data Fig. 6

a, Heatmap of molecularly defined single MkPs replenished by single Vwf-tdTomato− Multi-HSCs (Multi-MkPs; red) and Vwf-tdTomato+ P-HSCs (P-MkPs; blue) clustered based on expression of the 100 most differentially expressed genes (DEGs). b, Distribution of CD48 and Vwf-tdTomato protein/reporter level based on index data from FACS within molecularly defined Multi-MkPs and P-MkPs. **** P < 0.0001 by two-sided Wilcoxon test. P values: CD48-APC = 1.69 × 10−22, Vwf-tdTomato = 1.89 × 10−26.

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