Fig. 3: Genotype and environment drive immune variation in T and B cell responses.
From: Genetic and environmental interactions contribute to immune variation in rewilded mice
a, Representative histogram from Blocks 1 and 2 showing concatenated files from T. muris-infected and rewilded mice of each mice strain. b, Bar plots depicting MFI of CD44 on MLN CD4+ T cells. c–e, Representative histogram showing concatenated files from different groups of mice in Block 2 (c) with corresponding bar plots depicting proportion (d) and numbers (e) of B cells expressing CD44 on MLN cells. For b, d and e, n = 126; 129S1 Lab Uninfected = 8, 129S1 Lab T. muris = 9, 129S1 RW Uninfected = 8, 129S1 RW T. muris = 12, C57BL/6 Lab Uninfected = 8, C57BL/6 Lab T. muris = 11, C57BL/6 RW Uninfected = 18, C57BL/6 RW T. muris = 16, PWK/PhJ Lab Uninfected = 8, PWK/PhJ Lab T. muris = 6, PWK/PhJ RW Uninfected = 7, PWK/PhJ RW T. muris = 15 over two experimental blocks. For b, d and e one-way ANOVA test was used to test statistical significance between the different groups of interest. Data are displayed as mean ± s.e.m. and for b, d and e bar plots dots represent individual mice. NS P > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Inf, infected; RW, rewilded; Uninf, uninfected.
