A healthy immune system is tolerant to self-antigens while maintaining responsiveness to foreign threats. Co-expression of the inhibitory receptors PD-1 and CD73 regulates tolerance by restricting the expansion of auto-reactive CD4+ T cells independently of thymic selection.
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Brambley, C.A., Baker, B.M. Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73. Nat Immunol 26, 9–10 (2025). https://doi.org/10.1038/s41590-024-02039-w
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DOI: https://doi.org/10.1038/s41590-024-02039-w
