Fig. 2: Structural analysis of NLRP3 variants. | Nature Immunology

Fig. 2: Structural analysis of NLRP3 variants.

From: Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants

Fig. 2

a,b. Distance between Cys261 and Phe304 or Cys261 in the inactive (a) or active (b) NLRP3 structure (PDB: 7PZC and 8EJ4). c, Molecular interactions of ATPγS with WT or mutant (Mut) NLRP3 (PDB: 8EJ4). d, Mapping of variants within contact range with ATPγS in active NLRP3 structure (PDB: 8EJ4). Residues are highlighted as sticks and in color scale based on the mean value of ASC50 of variants that occurred at the designated sites (n value for each variant is listed in Supplementary Table 1). e, Variants at the interface of active NLRP3 oligomers (PDB: 8EJ4). f, Variants at the interface of inactive NLRP3 decamer (PDB: 7PZC). g, Variants at the interface of PYD filament (PDB: 7PZD).

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