Extended Data Fig. 9: The SSTR2-SST axis does not control DN T cell progenitor representation in the thymus.
From: An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines
(a) % of DN1; 1-2 transitional; 2 and 3 cells among DN1-3 T cell-committed progenitors at weaning. (b) Double positive, single positive and double negative thymocyte subsets cellularity in WT vs Sstr2−/− mice at weaning. (c) WT CD45.1 vs Sstr2−/− CD45.2 ratio in CD90 + CD44 + CD25 + SCA1+ cKIT+ α4β7 + thymocytes from competitive BM chimeras set up 2 days (P2) or 8 weeks after birth (8w). Results are normalized to the average of total TCRαβ + CD4+, TCRαβ + CD8β+ and B cell ratio in the spleen. Data are shown as mean ± SEM (n = 6 to 8 per group) and are representative of 2 independent experiments. Unpaired two-tailed T-test. *P ≤ 0.05. DN = double negative, indicating CD4- CD8β-.
