Supplementary Figure 11: Mutation signatures of human primary tumors compared with metastases.
From: In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens
a, Bar plot of the mutation frequencies associated with the 26 genes represented in the MCAP-MET library, in the TCGA PanCan primary tumor dataset (left) and the MET500 metastasis dataset (right). b, Scatter plot comparing the mutation frequencies in a (n = 26 genes). Spearman R = 0.799, P = 9.887 × 10–7. c,d, Venn diagrams of JAK1 and KMT2C (c) or CHD1 and KMT2D (d) mutations in the MET500 (n = 486 tumors) and TCGA PanCan cohorts (n = 9,870 tumors). Statistical significance of the overlap was assessed by hypergeometric test.
