Supplementary Figure 6: Representation of MCAP-MET crRNA array library in plasmid, cells, primary tumors and lung metastases.
From: In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens
a, Heat map of pairwise Spearman correlation coefficients of crRNA array log2 RPM abundance from MCAP-MET plasmid library (n = 1), MCAP transduced cells before transplantation (day 7 or 14 post infection, n = 6 cell replicates), primary tumors (n = 10 mice), and lung metastases (n = 37 from ten mice). b, Tukey box plots (IQR boxes, with 1.5 × IQR whiskers and all points overlaid) of crRNA array abundances (n = 11,934 arrays) from MCAP-MET profiling experiments. MCAP-MET plasmid library (n = 1), MCAP transduced cells before transplantation (day 7 or 14 post infection, n = 6 cell replicates), primary tumors (n = 10 mice) and lung metastases (n = 37 from ten mice).
