Extended Data Fig. 4: Archaeon Methanobrevibacter smithii found along the lower GI tract.

From shotgun sequencing, we detected participant CT12 had low levels of Methanobrevibacter smithii present in the terminal ileum, descending colon, and rectal biopsies (N = 3 biological replicates; error bars are 95% CI centered on the mean). MAG construction was performed on co-assembly of all biopsies taken from the terminal ileum and descending colon to reconstruct a full Methanobrevibacter smithii genome (completeness: 100%, redundancy: 0%).