Extended Data Fig. 9: The signals in the mouse NAc and mPFC during Pavlovian conditioning.
From: Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo
a, Representative fluorescence signals recorded during consecutive water trials pre (top, control) and post SCH-23390 (bottom, SCH-23390) treatment. The audio and water delivery are indicated above. b, Averaged traces of rDA3m (left) and ACh3.0 (right) fluorescence measured in the NAc from a mouse under control condition or in the presence of SCH-23390 in one mouse, mean±s.e.m. The grey shaded area indicates the application of audio. The dashed line indicates the delivery of water. c, Group summary of the peak fluorescence change of rDA3m and ACh3.0 signals in the NAc under the indicated condition. n = 155 trials from 3 mice for each group, mean±s.e.m. Two-tailed Student’s t-test was performed between control and SCH-23390 group. p = 0.2624 for ACh3.0. d, e. same as (b, c) with simultaneously recorded rDA3m and ACh3.0 signals in the mPFC. Two-tailed Student’s t-test was performed between control and SCH-23390 group. p = 0.2274 for ACh3.0.
