Supplementary Figure 4: The loss of miR-137 in germline leads to synaptic overgrowth. | Nature Neuroscience

Supplementary Figure 4: The loss of miR-137 in germline leads to synaptic overgrowth.

From: Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Supplementary Figure 4

a–b, IHC staining of PSD-95 and Synaptophysin in miR-137 gKO mice. Significant higher PSD-95 and Synaptophysin fluorescence intensity were observed in the CA1 region of the hippocampus in 8-week-old Mir137+/– mice (n = 4 mice; tPSD-95 = 2.841, P = 0.0295; tSynaptophysin = 5.912, P = 0.0010) (a) and P18-old Mir137–/– mice (n = 6; tPSD-95 = 3.206, P = 0.0094; tSynaptophysin = 2.987, P = 0.0136) (b). Data shown are means ± s.e.m. Unpaired Two-Tailed t test; *, P < 0.05; **, P < 0.01.

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