Supplementary Figure 10: Correlation of MECP2-dependent gene expression with DNA methylation in individual Rett syndrome donors.
From: Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing
Significantly misregulated genes (FDR < 0.1, monocle2) were determined by comparing mutant and wild-type excitatory neurons within the same individual donor. For each of the three donors, the mean fold-change in gene expression between mutant and wild-type excitatory neurons within the same individual were compared to gene body DNA methylation level derived from human excitatory neurons (mCH/CH, 100 gene bins, 10 gene step). The lines in E-G represent mean fold-change in expression for genes binned as described; the ribbon is s.e.m. of each bin.
