Supplementary Figure 9: QQ plot for discovery meta-analysis of AD.
QQ plot of two-tailed p-values for association with AD in the discovery meta-analysis of AA and EU cohorts (ncase=14,904, ncontrol=37,944). Meta-analysis is performed using effective sample size-based weights in a fixed effects model. Moderate deviation from the expected null distribution is observed, but this inflation is restricted to the upper tail of results (lambda=0.962). LD score regression within each ancestry suggests that true polygenic effects for AD are the primary source of deviations from the null distribution within both the EU (lambda=1.053, intercept=1.018, ratio=0.298) and AA (lambda=1.007, intercept=0.991-0.997; see Supplementary Information) ancestry analyses.
