Supplementary Figure 1: Results for ADH locus from transancestral modeling of unrelated individuals. | Nature Neuroscience

Supplementary Figure 1: Results for ADH locus from transancestral modeling of unrelated individuals.

From: Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Supplementary Figure 1

Regional association plot for the ADH gene region in trans-ancestral meta-analysis of unrelated genotyped individuals from AA and EU cohorts (ncase=11,476, ncontrol=23,080). Association with AD across ancestries was evaluated using (A) an inverse-variance weighted fixed-effects model, (B) the modified random-effects model92, and (C) the Bayesian trans-ancestral model93. The Bayesian model is fit with default priors and Metropolis-Hastings Markov chain Monte Carlo algorithm in MANTRA. Due to LD differences across ancestral groups combined in the trans-ancestral models LD is not indicated. The fixed-effects and random-effects models report conventional p-values, while the Bayesian model reports the Bayes factor for comparison of the null and alternative hypotheses. A log10 Bayes factor > 6.1 roughly corresponds the P < 5 × 10–8 significance threshold94. Plots generated with LocusZoom170 (http://locuszoom.sph.umich.edu/). See Supplementary Information for references.

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