Supplementary Figure 4: Variant groups for rare missense variant rate comparison. | Nature Neuroscience

Supplementary Figure 4: Variant groups for rare missense variant rate comparison.

From: Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

Supplementary Figure 4

a) Mean rare missense variants/person, MPC ≥ 2 only. b) Mean rare missense variants/person, MPC < 2 only. c) Mean rare synonymous variants/person, all genes. ‘Rare’ as described in the main text. * denotes p (compared to controls) < 0.05; ** denotes p < 0.01; *** denotes p < 0.001; all p values by logistic regression. For exact p values, see Supplementary Table 1. Sample numbers are as follows: ASD, no ID: 3,091; ASD+ADHD, no ID: 684; ADHD, no ID: 3,206; ASD, ID: 871; ASD+ADHD, ID: 217; ADHD, ID: 271; Control: 5,002. ID = intellectual disability. Error bars are Poisson standard error.

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