Extended Data Fig. 1: Male and female PS19 mice have similar tau pathology. | Nature Neuroscience

Extended Data Fig. 1: Male and female PS19 mice have similar tau pathology.

From: Microglial microRNAs mediate sex-specific responses to tau pathology

Extended Data Fig. 1

(a–c,e,f) Representative images of MC1 immunostaining of 9-month-old PS19 female (a) and male (b) hemibrains. Scale bar, 600 μm. Yellow dashed boxes magnified in (c). Scale bar, 300 μm. (e) Representative image of hippocampus. Scale bar, 600 μm. Yellow dashed boxes magnified in (f). Scale bar, 150 μm. 2 independent experimental cohorts were used. (d,g) MC1 density of entire hemibrain (d) and hippocampus (g) of nontransgenic (–) and transgenic (+) male and female mice. n = 11 nontransgenic females, 5 nontransgenic males, 10 PS19 females, and 9 PS19 males. Boxplot elements: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range.

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