Extended Data Fig. 10: Metabolic analysis of developmental glutamatergic neurons cultured in activated microglia-conditioned media. | Nature Neuroscience

Extended Data Fig. 10: Metabolic analysis of developmental glutamatergic neurons cultured in activated microglia-conditioned media.

From: Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia

Extended Data Fig. 10

a, Analysis of oxidative phosphorylation (ATP Production) and glycolysis (Baseline Glycolysis and Glycolytic Reserve) in HC glutamatergic neurons using a Seahorse Analyzer. Data are presented as mean±SEM. Two-Level Hierarchical Linear Mixed Effect Model was used for analysis (n=4 independent differentiations from 2 lines, each line with 2 independent differentiations). b, Analysis of oxidative phosphorylation (ATP Production) and glycolysis (Baseline Glycolysis and Glycolytic Reserve) in SCZ glutamatergic neurons using a Seahorse Analyzer. Data are presented as mean±SEM. Two-Level Hierarchical Linear Mixed Effect Model after log transformation was used for analysis of ATP Production and Glycolytic Reserve and Two-Level Hierarchical Linear Mixed Effect Model was used for analysis of Baseline Glycolysis (n=4 independent differentiations from 2 lines, each line with 2 independent differentiations). c, Analysis of oxidative phosphorylation in HC glutamatergic neurons vs. SCZ glutamatergic neurons cultured with or without activated microglia HMC3-conditioned media. Data are presented as mean±SEM. One-Level Hierarchical Linear Mixed Effect Model was used for analysis (n=4 independent differentiations from 2 lines, each line with 2 independent differentiations).

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