Extended Data Fig. 7: Inhibitory neurons from Mathys et al. also do not show differences in resilience or vulnerability to AD.
From: Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
a, tSNE projection of inhibitory neurons from Mathys et al.14 in the alignment space, colored by subpopulation identity (top) or individual of origin (bottom). b, Heatmap and hierarchical clustering of subpopulations and subpopulation markers (top subpanel); “High” and “Low” relative expression reflect above- and below-average expression, respectively (see Methods). Relative abundance of subpopulations in in AD cases vs. controls, separated by sex (second and third subpanels); for each sex, statistical significance of differences in relative abundance between AD cases vs. controls (cases n=12, controls n=12, where n is the number of individuals sampled) was determined by beta regression and adjusted for multiple comparisons (see Methods). Expression heatmap of inhibitory neuron subtype markers from Lake et al.12 (bottom subpanel).
